Selected publications


Styr, B. & Slutsky, I. (2018). Imbalance between firing homeostasis and synaptic plasticity drives early-phase Alzheimer’s disease. Nature Neuroscience 21(4), 463-473. [PDF] [F1000 recommendation]

Frere, S. & Slutsky, I. (2018). Alzheimer’s Disease: From Firing Instability to Homeostasis Network Collapse. Neuron 97(1), 32-58. [PDF]

Milshtein-Parush*, H., Frere*, S., Regev, L., Lahav, C., Benbenishty, A., Ben-Eliyahu, S., Goshen, I., and Slutsky, I. (2017). Sensory Deprivation Triggers Synaptic and Intrinsic Plasticity in the Hippocampus. Cerebral Cortex, Apr 12:1-14. doi: 10.1093/cercor/bhx084. [PDF]

Gazit N, Vertkin I, Shapira I, Helm M, Slomowitz E, Sheiba M, Mor Y, Rizzoli S, and Slutsky I (2016). IGF-1 receptor differentially regulates spontaneous and evoked transmission via mitochondria at hippocampal synapses. Neuron 89(3), 583-597. [PDF][Video abstract]

Frere, S & Slutsky, I (2016). Targeting PTEN interactions for Alzheimer’s disease. Nature Neurosci. 19: 416-418. [PDF]

Vertkin I, Styr B, Slomowitz E, Ofir N, Shapira I, Berner D, Fedorova T, Laviv T, Barak-Broner N, Greitzer-Antes D, Gassmann M, Bettler B, Lotan I, Slutsky I. GABAB receptor deficiency causes failure of neuronal homeostasis in hippocampal networks (2015). PNAS, doi: 10.1073/pnas.1424810112. [PDF].

Slomowitz E*, Styr B*, Vertkin I, Milshtein-Parush H, Nelken I, Slutsky M & Slutsky I. Interplay between population firing stability and single neuron dynamics in hippocampal networks (2015) eLife,   10.7554/eLife.04378. [PDF].

Fogel H*, Frere S*, Segev O, Bharill S, Shapira I, Gazit N, O’Malley T, Slomowitz E, Berdichevsky Y, Walsh DM, Isacoff EY, Hirsch JA, Slutsky I (2014) Amyloid-β activates presynaptic APP homodimers to increase release probability at excitatory synapses. Cell Reports 7:1560-1576.  [PDF] [Supplementary]

Dolev I*, Fogel H*, Milshtein H, Berdichevsky Y, Lipstein N, Brose N, Gazit N, Slutsky I (2013) Spike bursts increase amyloid-beta 40/42 ratio by inducing a presenilin-1 conformational change. Nature Neurosci. 16: 587-595. [PDF]

Laviv T, Vertkin I, Berdichevsky Y, Fogel H, Riven I, Bettler B, Slesinger PA, Slutsky I (2011) Compartmentalization of the GABAB Receptor Signaling Complex Is Required for Presynaptic Inhibition at Hippocampal Synapses. The Journal of Neuroscience 31: 12523-12532. [PDF]

Laviv T*, Riven I*, Dolev I, Vertkin I, Balana B, Slesinger PA, Slutsky I (2010) Basal GABA Regulates GABA(B)R Conformation and Release Probability at Single Hippocampal Synapses. Neuron 67: 253-267.  [PDF]

Highlighted by Nature Reviews Neuroscience 11, 664 (2010). [PDF]

Slutsky I*, Abumaria N*, Wu LJ, Huang C, Zhang L, Li B, Zhao X, Govindarajan A, Zhao MG, Zhuo M, Tonegawa S, Liu G (2010) Enhancement of Learning and Memory by Elevating Brain Magnesium. Neuron 65: 165-177.  [PDF]

Accompanied by preview in Neuron by A. Bush, 143-114. [PDF]

Abramov E*, Dolev I*, Fogel H, Ciccotosto GD, Ruff E, Slutsky I (2009) Amyloid-[beta] as a positive endogenous regulator of release probability at hippocampal synapses. Nature Neurosci 12: 1567-1576. [PDF]

Slutsky I, Sadeghpour S, Li B, Liu G (2004) Enhancement of synaptic plasticity through chronically reduced Ca2+ flux during uncorrelated activity. Neuron 44: 835-849. [PDF].

Accompanied by preview in Neuron by G. Awatramani and T.H. Murphy, 743-744. [PDF]